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We demonstrated that the TSS pathway is ineffective in supraphysiological cystine concentrations but is critical under physiological cystine supplementation or excess hemin exposure in SCD erythroblasts
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The inhibition of CMPK2 expression following FTO reduction led to decreased mtDNA production and cGAS-STING signaling activation, thereby suppressing inflammatory cytokine expression and ameliorating arthritis (61)
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