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The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade

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In addition, IGF-1 LR3 may promote fat breakdown by activating the MAPK pathway, leading to increased levels of free fatty acids and further exacerbating insulin resistance, forming a vicious cycle

Pol Arch Med Wewn 119:478486 Crewe HK, Lennard MS, Tucker GT, Woods FR, Haddock RE (1992) The effect selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes