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insulin is broken down by the stomach acid Concentration the higher the concentration, the more drug that is absorbed (usually!) Ionisation ionised particles cannot diffuse across membranes this plays a part in the mechanism of action for local anaesthetics Solubility drugs that are more polar (see below) are less readily absorbed through the lipid bilayer of the cell membrane Physical state of the drug e.g

Zhao JV, Schooling CM

Together, these complementary mechanisms provide researchers with a broader understanding of tissue physiology than any individual peptide alone

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