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As an alternative approach to improve in vivo stability of the fusion molecule, we then engineered a disulphide bridge into the exendin-4 peptide moiety (Ab#2_DSB#1) as this has been shown to improve in vitro and in vivo stability of both GLP-1 and exendin-4 analogue peptides 36

Common reactions may include: Nausea, especially after the first few doses Flushing or warmth in the face or chest Headache Mild injection site reactions such as redness or tenderness Nausea is the most commonly reported side effect, but it often decreases with continued use as the body adjusts

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Geiger et al., 2008