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Evidence is conflicting as to whether adolescents meet some of the dependence criteria for adults described above, which are generally based on the premise that prolonged use is needed for dependence to be established

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2Chest Pain If you smoke and have chest pain that worsens when you laugh, cough or breathe deeply, it could be a sign of heart disease such as arteriosclerosis (hardening of the arteries) or atherosclerosis, a type of arteriosclerosis in which a buildup of plaque in your blood vessels can lead to a dangerous clot

"Looks can be deceiving," Rodriguez said on Wednesday during an interview with CBS Mornings