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Saxenda and Wegovy are authorised for weight management and Mounjaro is authorised for both diabetes and weight management

To minimize discomfort, try eating smaller, more frequent meals and stick to bland options like crackers, toast, or rice

Full geometry optimizations, relaxed scans and transition structure searches were carried out with Gaussian 16 83 with the ONIOM 84 QM/MM method using the B3LYP hybrid functional 85 and 6-31 G(d) basis set with ultrafine integration grids for the QM part and the ff14SB 78 , gaff2 79 and TIP3P 86 force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding

For samples run on the ZIC-pHILIC column, the MS scan range (m/z) was set to 60900