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For instance, a prospective cohort study indicated that patients with higher levels of CRP and IL-6 were more likely to experience significant reductions in semen quality, reinforcing the idea that systemic inflammation may exacerbate the local inflammatory environment within the reproductive tract (169)

IBM SPSS Statistics 30.0.0.0 for Windows was used for statistical analysis

A comprehensive literature search across multiple databases identified a total of 6,541 studies, retrieved from PubMed ( n = 848), Web of Science ( n = 1,015), Scopus ( n = 2,523), Embase ( n = 1,525), Cochrane ( n = 367), as well as Google Scholar and manual reference searches ( n = 263)