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The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations
Amylin biology supports a genuine postprandial signature slower nutrient delivery, suppressed postprandial glucagon, reduced meal size and the cagrilintide-plus-semaglutide diabetes data are consistent with a maintained postprandial glucose benefit
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Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices
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