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They were originally developed to treat type 2 diabetes, but in recent years have become FDA-approved specifically for obesity under certain brand names like Wegovy and Zepbound

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Two of the field-defining dihexa papers from the Journal of Pharmacology and Experimental Therapeutics were formally retracted in April 2025 for falsified and fabricated image data, with the retraction attributing the misconduct to Leen Kawas and James Harding (retraction record