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During calorie restrictionespecially rapid weight lossthe body may break down muscle tissue for energy, which can slow metabolism and make long-term weight maintenance more difficult

Patients at JosephCareRX often report that combining Ozempic with lifestyle modificationssuch as dietary adjustments and regular physical activityenhances its effectiveness, making it a practical option for both diabetes management and weight loss

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As of April 7, 2025, the court has not issued a final ruling on the preliminary injunction for Semaglutide, though a related case for Tirzepatide saw a denial on March 5, 2025 (US FDA to Hold off Action)