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Similarly, while methionine supplementation has been shown to increase GSH levels in those with sub-optimal levels [115, 116], excess intakes in healthy individuals may increase homocysteine levels which has been shown to contribute to cardiovascular disease and several mental health disorders [117, 118]

For most users, noticeable improvements appear gradually over weeks of consistent use, though individual results can vary

The gap between the gene expression research (which suggests systemic biological effects) and the actual human evidence (which is limited to topical skin endpoints) is substantial

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