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Furthermore, the GCGR may play a role in renal energy metabolism, and GLP-1R/GCGR dual agonists such as 1907B have shown superior efficacy to GLP-1R single agonists in murine DN models, more effectively reducing proteinuria and improving renal function [232]

and vascular proliferation

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( l-n ) Correlation of tumour burden with circulating BHB ( l ), glucose ( m ), and NEFAs ( n ) at sacrifice