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Furthermore, catalpol can inhibit the ubiquitination and degradation of PTEN, block the NF-B and AKT signaling pathways, and prevent the differentiation of bone marrow-derived macrophages (BMMs) and RAW264.7 cells induced by receptor activator of nuclear factor kappa-B ligand (RANKL) into osteoclasts

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[DOI] [PubMed] [Google Scholar] 125.Chatterjee S., Rhee Y., Chung P.S., Ge R.F., Ahn J.C

Tendon and ligament repair, gastrointestinal mucosal healing, soft tissue recovery, and neuroprotective signaling are all supported by reproducible rodent and in vitro work, while the human evidence remains limited to one unpublished Phase 2 IBD trial and a small number of preliminary studies