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An important advantage of SLNs is that they are made from physiological, biodegradable lipids (e.g., triglycerides and fatty acids), many of which are Generally Recognized as Safe (GRAS) for food use (41, 42)

A recent 2024 network meta-analysis confirmed that an oral dose of 600 mg/day of ALA effectively lowers the Total Symptom Score (TSS) and the Neuropathy Impairment Score (NIS) compared to a placebo

The effects of SG on body weight and glucose tolerance are attenuated in the absence of FXR (169) and in TGR5 knock-out mice (170)