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228 In addition to regulating sodium and volume homeostasis, atrial natriuretic peptide functions as an endocrine factor in the heartliver axis by activating cGMP-protein kinase G-AKT-GSK3 signaling, leading to the regulation of liver glycogen metabolism
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The ability of NRF2 to regulate xCT coupled with the decline of NRF2 with age 178 might account for the increased levels of plasma cystine seen with increasing age
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