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Furthermore, vaccination for pneumococcal disease and influenza is required prior to the start of treatment and inactivated trivalent influenza vaccine should be given annually ( The common adverse drug reactions associated with thiopurines are leukopenia, hepatotoxicity, pancreatitis, and gastric intolerance ( Another concern over thiopurine therapy is an increased risk of malignancy, specifically lymphoproliferative disorder

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-Synuclein has been identified as a major protein component of Lewy bodies and plays a significant role in the pathogenesis of PD [219]