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Cytokine profiling using immunology multiplex assay MCP-1/CCL2, IL-6, and TNF-alpha (TNF) were measured in fasted plasma collected at endpoint using the Milliplex MAP Mouse Metabolic Hormone Magnetic Bead Panel in the Luminex MAGPIX system (EMD Millipore, Billerica, MA)

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In trials, tirzepatide (Zepbound for weight loss and Mounjaro for diabetes treatment) also reduced A1C better than semaglutide (Wegovy and Ozempic)

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